Symbol
Name
ID

Nckap1l
NCK associated protein 1 like
MGI:1926063

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Increased circulating IgG level	Increased B cell count	Increased proportion of memory T cells	Hepatosplenomegaly
Disease(s) Associated with NCKAP1L
immunodeficiency 72

Mouse Phenotypes

impaired neutrophil chemotaxis

decreased T cell proliferation

impaired macrophage phagocytosis

impaired neutrophil phagocytosis

abnormal thymus lobule morphology

thymus hypoplasia

spleen hyperplasia

abnormal common myeloid progenitor cell morphology

abnormal lymphopoiesis

abnormal CD4-positive T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

extramedullary hematopoiesis

hypochromic microcytic anemia

abnormal erythroid progenitor cell morphology

decreased hematocrit

decreased mean corpuscular volume

acanthocytosis

dacryocytosis

poikilocytosis

schistocytosis

increased neutrophil cell number

decreased mature B cell number

decreased B cell number

decreased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

decreased mature gamma-delta T cell number

abnormal regulatory T cell number

decreased lymphocyte cell number

increased leukocyte cell number

reticulocytosis

increased erythrocyte osmotic fragility

Availability

Mouse Genotype

Nckap1l^m1Btlr/Nckap1l^m1Btlr

Nckap1l^m1Iri/Nckap1l^m1Iri

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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